Impact of scaling and root planing on C-reactive protein levels in gingival crevicular fluid and serum in chronic periodontitis patients with or without diabetes mellitus
Mohan Mahendra, Jhingran Rajesh, Bains Vivek Kumar, Gupta Vivek, Madan Rohit, Rizvi Iram, Mani Kanchan,
소속 상세정보
( Mohan Mahendra ) - Saraswati Dental College & Hospital Department of Periodontology
( Jhingran Rajesh ) - Saraswati Dental College & Hospital Department of Periodontology
( Bains Vivek Kumar ) - Saraswati Dental College & Hospital Department of Periodontology
( Gupta Vivek ) - Rama Dental College Hospital Department of Periodontology
( Madan Rohit ) - Saraswati Dental College & Hospital Department of Periodontology
( Rizvi Iram ) - Saraswati Dental College & Hospital Department of Periodontology
( Mani Kanchan ) - Kshitiz Medical & Diagnostic Clinic
KMID : 0363020140440040158
Abstract
Purpose: The present study was conducted to evaluate the impact of scaling and root planing (SRP) on the C-reactive protein (CRP) levels of gingival crevicular fluid (GCF) and serum in chronic periodontitis patients with type 2 diabetes mellitus (T2DM-CP) or without type 2 diabetes mellitus (NDM-CP).
Methods: Forty-eight human participants were divided into two groups: an experimental (T2DM-CP) group (group I, n=24) comprising chronic periodontitis patients with random blood sugar ≥200 mg/dL and type 2 diabetes mellitus, and control (NDM-CP) group (group II, n=24) of those with chronic periodontitis and random blood sugar <200 without T2DM for the study. All subjects underwent nonsurgical periodontal therapy (NSPT) including complete SRP and subgingival debridement. Periodontal health parameters, plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), GCF volume (GCF vol), GCF-CRP, random blood glucose (RBS), glycated hemoglobin, and systemic inflammatory markers, serum CRP, total leukocyte count (TLC), neutrophil count (Neutr) and lymphocyte count (Lymph), were evaluated at baseline, 1 month, and 3 months after SRP.
Results: NSPT resulted in statistically significant improvement in periodontal health parameters (PI, GI, PPD, CAL, GCF vol), CRP levels in serum as well as GCF of both groups I and II. The mean improvement in periodontal health parameters (PI, GI, PPD, CAL, GCF vol), CRP levels in serum and GCF was greater in group I than group II after NSPT. There was nonsignificant increase in GCF-CRP, TLC, Lymph, and RBS, and a significant increase in Neutr and Serum CRP in group II at 1 month. The Serum CRP level of 20 out of 24 group II patients had also increased at 1 month.
Conclusions: The CRP levels in both GCF and serum were higher in T2DM-CP patients than in NDM-CP patients. Although there was a significant improvement in both the groups, greater improvement was observed in both GCF and serum samples of T2DM-CP patients.
키워드
Chronic periodontitis ; C-reactive protein ; Diabetes mellitus ; Root planning
원문 및 링크아웃 정보
등재저널 정보