Antioxidant Property of Vitamin C-in Comparison with Vitamin B1
Seo Du-Kyo, 김정희,
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( Seo Du-Kyo ) - 경희대학교 치과대학 구강생화학교실
김정희 ( Kim Jeong-Hee ) - 경희대학교 치과대학 구강생화학교실
KMID : 0848120050300040117
Abstract
Various aspects of antioxidant activity in vitamin C were evaluated in this study. Relatively high level of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was detected in vitamin C, but not in non-antioxidative vitamin, vitamin B1. Vitamin C also reduced the production of lipid peroxidation in Chinese hamster lung fibroblast (V79-4) cells with IC50 value of 4 ㎍/ml. Vitamin B1 showed comparable reduction in lipid peroxidation products (IC50 value was about 10㎍/ml). It was shown that vitamin C also dose-dependently enhanced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in V79-4 cells, and these effects were not observed in vitamin Bl-treated cells. Our data suggest that well-known antioxidant vitamin C involved in direct activation of SOD, CAT and GPX.
키워드
Vitamin C;Radical scavenging; Lipid peroxidation;Antioxidant enzymes
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