Wnt/β-Catenin 신호조절에 의한 백악질 형성의 이해
Understanding of Cementum Formation by the Wnt/β-Catenin ignaling
유영재, 양진영,
소속 상세정보
유영재 ( You Young-Jae ) - 전북대학교 치의학전문대학원 구강해부조직학교실
양진영 ( Yang Jin-Young ) - 대전과학기술대학교 치위생과
KMID : 1023420160160060401
Abstract
Periodontal disease is one of the major dental diseases. Currently, various methods are used for healing and successful regeneration of periodontal tissue damaged by periodontal disease. The periodontal ligament and alveolar bone have received considerable interest for use in periodontal tissue regeneration and induction. However, as the functions of the factors required for tooth attachment and key regulatory factors for periodontal tissue regeneration in the cementum have recently been identified, interest in cementum formation and regeneration has increased. Dental cementum forms in the late phase of tooth development because of the reciprocal regulatory interaction between cervical loop epithelial cells and surrounding mesenchymal cells, which is regulated by various gene signaling networks. Many attempts have been made to understand the regulatory factors and cellular and molecular mechanisms associated with new cementum formation. In this paper, we reviewed the study outcomes to date on the regulatory factors that induce cementum formation and regeneration, focusing on understanding the roles and functions of Wnt signaling in the regulation of cementum formation. In addition, we aimed to obtain information on the useful reciprocal regulatory factors that mediate cementum formation and regeneration through a series of molecular mechanisms.
키워드
Cementogenesis; Dental cementum; Epithelial mesenchymal transition; Wnt signaling pathway
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