Effects of ibuprofen-loaded TiO2 nanotube dental implants in alloxan-induced diabetic rabbits
김영교, 김완태, 정보현, 유기연, 엄흥식, 장범석, 이재관, 최원열,
소속 상세정보
김영교 ( Kim Young-Gyo ) - Gangneung-Wonju National University College of Dentistry Department of Periodontology
김완태 ( Kim Wan-Tae ) - Gangneung-Wonju National University Department of Advanced Materials Engineering
정보현 ( Jung Bo-Hyun ) - Gangneung-Wonju National University College of Dentistry Department of Anatomy
유기연 ( Yoo Ki-Yeon ) - Gangneung-Wonju National University College of Dentistry Department of Anatomy
엄흥식 ( Um Heung-Sik ) - Gangneung-Wonju National University College of Dentistry Department of Periodontology
장범석 ( Chang Beom-Seok ) - Gangneung-Wonju National University College of Dentistry Department of Periodontology
이재관 ( Lee Jae-Kwan ) - Gangneung-Wonju National University College of Dentistry Department of Periodontology
최원열 ( Choi Won-Youl ) - Gangneung-Wonju National University Department of Advanced Materials Engineering
Abstract
Purpose: Some systemic conditions, especially diabetes mellitus (DM), adversely affect dental implant success. This study aimed to investigate the effects of ibuprofen-loaded TiO2 nanotube (ILTN) dental implants in alloxan-induced diabetic rabbits.
Methods: Twenty-six New Zealand white rabbits were treated with alloxan monohydrate to induce DM. At 2 weeks following DM induction, 3 types of implants (sandblasted, large-grit, and acid-etched [SLA], ILTN, and machined) were placed into the proximal tibia in the 10 rabbits that survived following DM induction. Each type of implant was fitted randomly in 1 of the holes (round-robin method). The animals were administered alizarin (at 3 weeks) and calcein (at 6 weeks) as fluorescent bone markers, and were sacrificed at 8 weeks for radiographic and histomorphometric analyses.
Results: TiO2 nanotube arrays of ~70 nm in diameter and ~17 μm in thickness were obtained, and ibuprofen was loaded into the TiO2 nanotube arrays. A total of 26 rabbits were treated with alloxan monohydrate and only 10 rabbits survived. The 10 surviving rabbits showed a blood glucose level of 300 mg/dL or higher, and the implants were placed in these diabetic rabbits. The implant stability quotient (ISQ) and bone-to-implant contact (BIC) values were significantly higher in the ILTN group (ISQ: 61.8, BIC: 41.3%) and SLA group (ISQ: 62.6, BIC: 46.3%) than in the machined group (ISQ: 53.4, BIC: 20.2%), but the difference in the BIC percentage between the SLA and ILTN groups was not statistically significant (P=0.628). However, the bone area percentage was significantly higher in the ILTN group (78.0%) than in the SLA group (52.1%; P=0.000).
Conclusions: The ILTN dental implants showed better stability (ISQ) and BIC than the machined implants; however, these values were similar to the commercially used SLA implants in the 2-week diabetic rabbit model.
키워드
Alloxan; Dental implant; Diabetes mellitus; Ibuprofen; Nanotubes
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