Evaluation of superoxide dismutase 3, heme-oxygenase, and myeloperoxidase expression levels associated with oxidative stress in chronic periodontitis
윤용, 김혜린, 이재목,
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윤용 ( Yoon Yong ) - Kyungpook National University School of Dentistry Department of Periodontology
김혜린 ( Kim Hye-Rin ) - Kyungpook National University School of Dentistry Department of Periodontology
이재목 ( Lee Jae-Mok ) - Kyungpook National University School of Dentistry Department of Periodontology
Abstract
This study aimed to investigate the expression levels of antioxidative enzymes such as superoxide dismutase 3 (SOD3), heme-oxygenase (HO), and myeloperoxidase (MPOs), which are known to be associated with oxidative stress induction in chronic inflammatory conditions like periodontitis. We compared the expression levels of SOD3, HO, and MPO in the periodontal tissues of healthy individuals with those in the periodontal tissues of chronic periodontitis patients. The expression levels of SOD3, HO, and MPO were determined by Western blot technique, and the data were statistically analyzed. The expression levels of SOD3 and HO increased in periodontitis patients compared with those in healthy controls, and the degree of increase was dependent on the severity of periodontitis (p<0.05). In contrast, the expression level of MPO was lower in the periodontal tissues of healthy controls than that in the periodontal tissues of periodontitis patients (p<0.05). SOD and HO are involved in oxidative stress via antioxidative activity, and MPO is involved in oxidative stress via peroxidative activity. Hence, these findings suggest that antioxidative activity depends on the severity of inflammation. In conclusion, SOD3, HO, and MPO may play a role in oxidative stress-induced periodontitis, and these three factors may be related to the severity of inflammation. These factors are expected to be applied to the diagnosis and treatment of periodontitis through more comprehensive studies.
키워드
Chronic periodontitis; Heme oxygenase; Myeloperoxidase; Oxidative stress; Superoxide dismutase
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