Carbon-ion radiotherapy in osteosarcoma of the mandible: a case report
하태욱, 박슬마로, 윤민영, 김동욱, 김형준,
소속 상세정보
하태욱 ( Ha Tae-Wook ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
박슬마로 ( Park Slmaro ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
윤민영 ( Youn Min-Yeong ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
김동욱 ( Kim Dong-Wook ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
김형준 ( Kim Hyung-Jun ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
Carbon-ion radiotherapy (CIRT) is on the rise as a treatment choice for malignant tumor. Compared to conventional radiotherapy, particle beams have different physical and biological properties. Particle beam provides a low entry dose, deposits most of the energy at the endpoint of the flight path, and forms an asymptotic dose peak (the “Bragg peak”). Compared to protons, carbon with its larger mass decreases beam scattering, resulting in a sharper dose distribution border. We report a 50-year-old male who underwent CIRT without surgical resection on osteosarcoma of the mandible. After CIRT, the patient’s pain was gone, and the malignant mass remained stable with accompanying necrosis. Nine months later, however, magnetic resonance imaging demonstrated progression of the left mandibular osteosarcoma with pulmonary metastases. After multidisciplinary discussion, concurrent chemoradiotherapy was conducted. While necrotic bone segments came out of the mandible during subsequent periodic outpatient visits, the tumor itself was stable. Thirty months after his first visit and diagnosis, the patient is waiting for chemotherapy. Although CIRT is superior in treating radioresistant hypoxic disease, CIRT is in its infancy, so care must be taken for its indications and complications.
키워드
Osteosarcoma; Heavy ion radiotherapy; Radiotherapy; Head and neck neoplasms
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