유해자극에 의한 개구반사와 말초신경 흥분전도에 미치는 건간과 세신 추출물의 영향
Effect of zingiberis rhizoma and asiasari radix extracts on the jaw opening reflex provoked by noxious stimuli and the peripheral nerve conduction
류박영, 高福子,
소속 상세정보
류박영 ( ) - 서울대학교
高福子 ( ) - 서울대학교
KMID : 0362319920170010022
Abstract
The aim of this study was to investigate the effect of herbal organic extracts on the pain response provoked by noxious on dental nerve and the peripheral nerve conduction.
Cats (2-2.5Kg) regardless of sex) that were chosen as experimental animals were classified into control group, Asiasari radix application group and Zingiberis rhizoma application group. They were anesthetized with α-chloralose, then anterior
belly
of
digastric muscle of both sides were exposed and wire electrodes were inserted for recording of Electromyogram (EMG).
Cavities were prepared on canines until pulp of the teeth were exposed, And after the drugs solubilized for 2% and 4% concentration (W/V) in vehicle were applied, their effects were compared through the recording of EMG immediately after drug
application, 30 minutes, 60 minutes, 120 minutes and 5 days after, respectively. And after both inferior alveolar nerves were exposed, 4% organic extracts of Zingiberis rhizome and Asiasari radix were applied for 30 minutes then the change of jaw
opening reflex provoked by noxious stimuli on pulpal nerves were observed immediately after washing out, at 30, 60 and 90 minutes after drug had been washed out. After saphenous nerve of both sides were exposed, one side of nerve was used for
vehicle
application and the other side was used for drug application for 30 minutes. Then conduction of action potential of A-δ and C-fiders of saphenous nerves, which have changes with time, was recorded.
@ES With analysis of these records, the following results were obtained:
@EN 1. Organic extract of Zingiberis rhizoma (2% or 4% concentration) greatly suppressed EMG of digastric muscle provoked by noxious stimuli on pulpal nerve at five days after application, the suppressive effect was greater than that of organic
extract
of Asiasari radix.
2. Organic extract of Asiasari radix (2% or 4% concentration) suppressed jaw opening reflex provoked by noxious stimuli on pulpal nerve, at 5 days after drug application.
3. Organic extract of Zingiberis rhizoma and Asiasari radix (immediately after 30 minutes application) suppressed neural conduction of A-δ and C-fibers, the suppressive effect was greater on A-δ fibers than on C-fibers.
4. Jaw opening reflex provoked by noxious stimuli on pulpal nerve in inferior alveolar nerve was greatly suppressed 30 minutes after drug application, this effect was greater by Zingiberis rhizoma than by Asiasari radix.
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