SITE LINK

신경병증성 통증 환자에서 지속적 진통을 위한 5% 리도카인의 사용
The Use of 5% Lidocaine for Prolonged Analgesia in Neuropathic Pain Patients

대한치과마취과학회지 2003년 3권 1호 p.6 ~ 9

박승욱, 이두익, 김동옥, 김건식, 최영규, 권무일, 신광일,

소속 상세정보

박승욱 ( Park Sung-Wook ) - 경희대학교 의과대학 마취통증의학교실
이두익 ( Lee Doo-Ik ) - 경희대학교 의과대학 마취통증의학교실
김동옥 ( Kim Dong-Ok ) - 경희대학교 의과대학 마취통증의학교실
김건식 ( Kim Keon-Sik ) - 경희대학교 의과대학 마취통증의학교실
최영규 ( Choi Young-Kyu ) - 경희대학교 의과대학 마취통증의학교실
권무일 ( Kwon Moo-Il ) - 경희대학교 의과대학 마취통증의학교실
신광일 ( Shin Kwang-Il ) - 경희대학교 의과대학 마취통증의학교실

KMID : 0980220030030010006

Abstract

Background: The use of neurolytic agents to control neuropathic pain has been described from the last century. Phenol and ethyl alcohol have been widely used as neurolytic agents, however, their neurolytic effect is variable in efficacy and duration of action, and infrequently accompanied with grave complications. It has been found that 5% lidocaine causes irreversible conduction blockade in animal studies. The goal of this study was to evaluate the neurolytic effect of 5% lidocaine on various neuropathic pain syndromes for prolonged analgesia.

Methods: Twenty-five patients with a diagnosis of neuropathic pain including trigeminal neuralgia (n=7), postherpetic neuralgia (n=10), and postsurgical neuralgia (n=8) were selected after failure of routine therapeutic regimens. After performing a diagnostic nerve block with 1% lidocaine and 5% lidocaine was injected. The patients were followed for 6 months. Visual analog scale (VAS) scores and side effects were recorded for each patients.

Results: A significant decrease in pain scores after neurolytic blockade with 5% lidocaine was seen in all of three pain groups. All the patients reported immediate and prolonged pain relief lasting from 4 weeks to 6 months. None of patients exhibited any appreciable side effects or complications.

Conclusions: We suggest that 5% lidocaine may be used safely and effectively for the purpose of prolonged analgesia in selected patients with intractable neuropathic pain syndromes.