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백서에서 Gabapentin 전신투여가 Facial Formalin Test에 미치는 영향
The Effects of Gabapentin on Facial Formalin Test

대한치과마취과학회지 2003년 3권 2호 p.92 ~ 97

김철홍, 백승완, 김해규, 권재영, 김경훈, 최성환,

소속 상세정보

김철홍 ( Kim Cheol-Hong ) - 부산대학교 의과대학 마취통증의학교실
백승완 ( Baek Seung-Wan ) - 부산대학교 의과대학 마취통증의학교실
김해규 ( Kim Hae-Kyu ) - 부산대학교 의과대학 마취통증의학교실
권재영 ( Kwon Jae-Young ) - 부산대학교 의과대학 마취통증의학교실
김경훈 ( Kim Kyung-Hoon ) - 부산대학교 의과대학 마취통증의학교실
최성환 ( Choi Sung-Hwan ) - 부산대학교 의과대학 마취통증의학교실

KMID : 0980220030030020092 DOI : 10.17245/jkdsa.2003.3.2.92

Abstract

Background: Gabapentfn is a novel anti-epileptic dHg, which is used in clinical practice to treat epilepsy. This drug is also used as an analgesic in pain patients. The antinociceptive effect of this drug was assessed using the formatin test in the rat.

Methods: In order to investigate the effects of gabapentin on the trigeminal nerve territory, we injected 0.5% formalin into the upper lip. Adult, male, Sprague-Dawley rats received a 50 ㎖ subcutaneous injection of 5% formalin into one vibrissal pad and the consequent, facial grooming behavior was monitored. Consistent with previous investigations using the formalin model, animals exhibited biphasic nocifensive groomiag (phase 1, 0-12 min; phase 2, 12-60 min.

Results: The intraperitoncal administration gabapentin 5 minutes prior to the formalin injection led to a significaut, dose-dependent reduction in grooming time during phase 2. In high doses, gabapentin also reduced the time of grooming during phase 1.

Conclusions: The Intraperitoneal injection of gabapentin has an analgesic effect in the facial formalin rat modet and this analgesic effect increases dose-dependently.