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덱스메데토미딘의 임상 용량의 나이에 따른 변화

Effect of Age on Optimal Clinical Dose of Dexmedetomidine Sedation

대한치과마취과학회지 2014년 14권 3호 p.151 ~ 155
최윤지, 백재원, 노영진,
소속 상세정보
최윤지 ( Choi Yoon-Ji ) - 서울대학교 치과병원 치과마취과
백재원 ( Baik Jae-Won ) - 서울아산병원 마취통증의학과
노영진 ( Ro Young-JIn ) - 서울아산병원 마취통증의학과

Abstract


Background: Dexmedetomidine is known to be administered for sedation safely even in a very elderly patient. The purpose
of this study was to determine the effect of age on clinically optimal dose of dexmedetomidine for sedation.

Methods: We enrolled 50 patients ASA class I and II, scheduled for lower extremity surgery that need. They were classified into a young group (n = 26), aged below 75 and an old group (n = 24), aged above 75. Dexmedetomidine was continuously infused 0.5 μg/kg within 10 min, followed by maintenance at a dose of 0.5 μg/kg/min, initially. The next dose was selected using the Dixon’s up-and-down method.

Results: The cED50 of dexmedetomidine required to maintain optimal sedation level in young and old group were 0.50 and
0.48 μg/kg, respectively. With isotonic regression, cED95 of dexmedetomidine was 0.71 μg/kg (95% confidence intervals 0.57-1.06μg/kg) and 0.58 μg/kg (95% confidence intervals 0.51-0.67 μg/kg). There were no significant differences in cED50 (P = 0.21), recovery variables, or incidence of side effects between the two groups.

Conclusions: Clinically optimal dose of dexmedetomidine was not affected to the age during sedation.

키워드

Dexmedetomidine; Elderly; Sedation

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