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Effect Site Concentrations of Propofol for Dental Treatment under Deep Sedation in Intellectually Disabled Patients

대한치과마취과학회지 2014년 14권 3호 p.167 ~ 172
이승화, 신터전, 김현정, 최윤지, 이수언, 장주혜, 서광석,
소속 상세정보
이승화 ( Lee Seong-Hwa ) - 서울대학교 치과병원 치과마취과
신터전 ( Shin Teo-Jeon ) - 서울대학교 치의학대학원 소아치과학교실
김현정 ( Kim Hyun-Jeong ) - 서울대학교 치과대학 치과마취과학교실
최윤지 ( Choi Yoon-Ji ) - 서울대학교 치과대학 치과마취과학교실
이수언 ( Lee Soo-Eon ) - 서울대학교 치과대학 치과마취과학교실
장주혜 ( Chang Ju-Hea ) - 서울대학교 치과병원 장애인클리닉
서광석 ( Seo Kwang-Suk ) - 서울대학교 치과대학 치과마취과학교실

Abstract


Background: Propofol is the most commonly used anesthetic for sedation and target-controlled infusion (TCI) is useful for dental treatment. However, it is important to assess and maintain an adequate depth of sedation in patients with severe intellectual disabilities Therefore, in this study we aimed to evaluate the adequate propofol target concentration for dental treatment in severely intellectually disabled patients.

Methods: We undertook retrospective review of the sedation records of severely intellectually disabled patients who underwent dental treatment under TCI propofol sedation from September 2011 to April 2012. We evaluated the initial target concentration, stabilized concentration of propofol and monitored vital signs, including BIS score using sedation records.

Results: Total 20 patients (10 male and 10 female patients) were included in the study. Every participant was severely intellectually disabled. The mean sedation duration was (45-100) minutes. The initial propofol target concentration infusion amount was (2.0-3.0) mcg/ml. The propofol effect site concentration (Ce) was (1.0-4.0) mcg/ml. The average value of BIS was (28-81). During the treatment period, there were no severe complications.

Conclusions: The average propofol Ce for deep sedation without any complications in intellectually disabled patients was 2.6 mcg/ml.

키워드

Deep sedation; Mentally disabled persons; Propofol

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