CT evaluation of underlying bone sclerosis in patients with oral squamous cell carcinoma: A preliminary retrospective study
조규동, 이원진, 허민석, 이삼선, 최순철, 허경회,
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조규동 ( Jo Gyu-Dong ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Radiology
이원진 ( Yi Won-Jin ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Radiology
허민석 ( Heo Min-Suk ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Radiology
이삼선 ( Lee Sam-Sun ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Radiology
최순철 ( Choi Soon-Chul ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Radiology
허경회 ( Huh Kyung-Hoe ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Radiology
Abstract
Purpose: Underlying bone sclerosis is frequently observed in clinical settings when oral squamous cell carcinoma (OSCC) invades the jaw bone. The aim of this study was to assess the prevalence and characteristics of underlying bone sclerosis in patients with OSCC.
Materials and Methods: We retrospectively reviewed the computed tomographic (CT) images of 131 patients who underwent mandibulectomy between January 2012 and December 2015 to treat OSCC. The presence, degree, and extent of underlying bone sclerosis were assessed on CT images and correlated with the following imaging patterns of bone invasion: cortical invasion, medullary invasion with a smooth margin, and medullary invasion with an irregular margin. The chi-square test was used to determine the relationships between the variables.
Results: The prevalence of underlying bone sclerosis on CT images was 70.1% (47 of 67). The prevalence was 85.7% (42 of 49) in patients with medullary invasion, but it was 27.8% (5 of 18) in patients with only cortical invasion, indicating a significant increase in the prevalence of underlying bone sclerosis in patients with medullary invasion (P<.05). Aggressive patterns of bone invasion were associated with increases in the degree and extent of the underlying bone sclerosis (P<.05).
Conclusion: More than two-thirds of OSCC cases with bone invasion showed underlying bone sclerosis. On CT images, reactive sclerosis in the remaining margin of the alveolar bone should not be used as the primary means to differentiate periodontal inflammatory lesions from those resulting from OSCC.
키워드
Carcinoma; Squamous Cell; Sclerosis; Mandible; Tomography; X-ray Computed
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