CBCT imaging and histopathological characteristics of osteoradionecrosis and medication-related osteonecrosis of the jaw
Ogura Ichiro, Minami Yoshiyuki, Ono Junya, Kanri Yoriaki, Okada Yasuo, Igarashi Kensuke, Haga-Tsujimura Maiko, Nakahara Ken, Kobayashi Eizaburo,
소속 상세정보
( Ogura Ichiro ) - Nippon Dental University School of Life Dentistry at Niigata Department of Oral and Maxillofacial Radiology
( Minami Yoshiyuki ) - Nippon Dental University School of Life Dentistry at Niigata Department of Oral and Maxillofacial Radiology
( Ono Junya ) - Nippon Dental University School of Life Dentistry at Niigata Department of Pathology
( Kanri Yoriaki ) - Nippon Dental University School of Life Dentistry at Niigata Department of Pathology
( Okada Yasuo ) - Nippon Dental University School of Life Dentistry at Niigata Department of Pathology
( Igarashi Kensuke ) - Nippon Dental University School of Life Dentistry at Niigata Department of Dental Materials Science
( Haga-Tsujimura Maiko ) - Nippon Dental University School of Life Dentistry at Niigata Department of Histology
( Nakahara Ken ) - Nippon Dental University School of Life Dentistry at Niigata Advanced Research Center
( Kobayashi Eizaburo ) - Nippon Dental University School of Life Dentistry at Niigata Department of Oral and Maxillofacial Surgery
Abstract
Purpose: The purpose of this study was to evaluate the cone-beam computed tomographic (CBCT) imaging and histopathological characteristics of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ).
Materials and Methods: Ten surgical specimens from segmental mandibulectomy (3 ORN and 7 MRONJ) were analyzed using CBCT. The CBCT parameters were as follows: high-resolution mode (tube voltage, 90.0 kV; tube current, 4.00 mA; rotation time, 16.8 s; field of view, 56 mm×56 mm; thickness, 0.099 mm). Histopathological characteristics were evaluated using histological slides of the surgical specimens. The Pearson chi-square test was used to compare ORN and MRONJ in terms of CBCT findings (internal texture, sequestrum, periosteal reaction and cortical perforation) and histopathological characteristics (necrotic bone, inflammatory cells, reactive bone formation, bacteria, Actinomyces, and osteoclasts). A P value less than 0.05 was considered to indicate statistical significance.
Results: MRONJ showed periosteal reaction on CBCT more frequently than ORN (7 of 7 [100%] vs. 0 of 3 [0%], P<0.05). Regarding histopathological characteristics, MRONJ showed osteoclasts more frequently than ORN (6 of 7 [85.7%] vs. 0 of 3 [0%], P<0.05).
Conclusion: This study evaluated the CBCT imaging and histopathological characteristics of ORN and MRONJ, and the findings suggest that CBCT could be useful for the evaluation of ORN and MRONJ.
키워드
Bisphosphonate-Associated Osteonecrosis of the Jaw; Osteoradionecrosis; Cone-Beam Computed Tomography
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