A rare case of Ewing sarcoma metastasis to the oral cavity
Schulz Rieli Elis, de Lima Matheus Henrique Alves, Lopes Rodrigo Nascimento, Pinto Clovis Antonio Lopes, Nicolau Ulisses Ribaldo, Araujo Juliane Piragine,
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( Schulz Rieli Elis ) - Brazil A. C. Camargo Cancer Center Department of Stomatology
( de Lima Matheus Henrique Alves ) - Brazil A. C. Camargo Cancer Center Department of Stomatology
( Lopes Rodrigo Nascimento ) - Brazil A. C. Camargo Cancer Center Department of Stomatology
( Pinto Clovis Antonio Lopes ) - A. C. Camargo Cancer Center Department of Anatomic Pathology
( Nicolau Ulisses Ribaldo ) - A. C. Camargo Cancer Center Department of Oncology
( Araujo Juliane Piragine ) - Brazil A. C. Camargo Cancer Center Department of Stomatology
Abstract
Ewing sarcoma in the head and neck is rare, and metastasis from other bones to the mandible accounts for 0.7% of cases. This report presents a case of oral metastasis in a 24-year-old male patient diagnosed with Ewing sarcoma of the femur (p53 gene mutation and EWSR1-ERG fusion). The chief complaint was numbness in the mandible and pain for 1 month and a hardened, ulcerated exophytic lesion in the right retromolar region. Imaging exams revealed an unspecified thinning of the cortical bone of the inferior alveolar canal in the right mandibular ramus, associated with erosion of the alveolar bone. Histopathological analysis confirmed metastasis of Ewing sarcoma. The patient presented an aggressive disease progression and died 1 month after the oral diagnosis. It is important to recognize the signs and symptoms compatible with rare clinical outcomes, leading to an early diagnosis that can improve patients’ quality of life and survival.
키워드
Sarcoma, Ewing; Neoplasm Metastasis; Mandible; Hypesthesia
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