Bone repair in defects filled with AH Plus sealer and different concentrations of MTA: a study in rat tibiae
Paz Jessica Emanuella Rocha, Costa Priscila Oliveira, Souza Albert Alexandre Costa, de Oliveira Ingrid Macedo, Falcao Lucas Fernandes, Falcao Carlos Alberto Monteiro, Ferraz Maria Angela Area Leao, Pinto Lucielma Salmito Soares,
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( Paz Jessica Emanuella Rocha ) - Sao Paulo University School of Dentistry Department of Oral and Maxillofacial Surgery and Periodontology
( Costa Priscila Oliveira ) - Uninovafapi University Center Dental School Department of Endodontics
( Souza Albert Alexandre Costa ) - Uninovafapi University Center Dental School Department of Endodontics
( de Oliveira Ingrid Macedo ) - Uninovafapi University Center Dental School Department of Endodontics
( Falcao Lucas Fernandes ) - Sao Leopoldo Mandic Dental School Department of Endodontics
( Falcao Carlos Alberto Monteiro ) - Uninovafapi University Center Dental School Department of Endodontics
( Ferraz Maria Angela Area Leao ) - Uninovafapi University Center Dental School Department of Endodontics
( Pinto Lucielma Salmito Soares ) - State University of Piaui Health Science Center Department of Morphology
Abstract
Objectives: This study aimed to evaluate the effects on bone repair of different concentrations of mineral trioxide aggregate (MTA) added to AH Plus.
Materials and Methods: Bone tissue reactions were evaluated in 30 rats (Rattus norvegicus) after 7 and 30 days. In the AH + MTA10, AH + MTA20, and AH + MTA30 groups, defects in the tibiae were filled with AH Plus with MTA in proportions of 10%, 20% and 30%, respectively; in the MTA-FILL group, MTA Fillapex was used; and in the control group, no sealer was used. The samples were histologically analyzed to assess bone union and maturation. The Kruskal-Wallis and Mann-Whitney tests were performed for multiple pairwise comparisons (p ≤ 0.05).
Results: At the 7-day time point, AH + MTA10 was superior to MTA-FILL with respect to bone union, and AH + MTA20 was superior to MTA-FILL with respect to bone maturity (p < 0.05). At the 30-day time point, both the AH + MTA10 and AH + MTA20 experimental sealers were superior not only to MTA-FILL, but also to AH + MTA30 with respect to both parameters (p < 0.05). The results of the AH + MTA10 and AH + MTA20 groups were superior to those of the control group for both parameters and experimental time points (p < 0.05).
Conclusions: The results suggest the potential benefit of using a combination of these materials in situations requiring bone repair.
키워드
AH Plus; Bone regeneration; Mineral trioxide aggregate; MTA Fillapex; Rattus norvegicus ; Root canal sealers
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