Association of maxillary dental developmental abnormality with precocious puberty: a case-control study
김예슬, 이남기, 김재현, 구정귀, 이부규, 정회인, 최선규,
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김예슬 ( Kim Ye-Sel ) - Yonsei University Department of Preventive Dentistry and Public Oral Health
이남기 ( Lee Nam-Ki ) - Seoul National University Bundang Hospital Section of Dentistry Department of Orthodontics
김재현 ( Kim Jae-Hyun ) - Seoul National University Bundang Hospital Department of Pediatrics
구정귀 ( Ku Jeong-Kui ) - Armed Forces Capital Hospital Section of Dentistry Department of Oral and Maxillofacial Surgery
이부규 ( Lee Bu-Kyu ) - Seoul Asan Medical Center Department of Oral and Maxillofacial Surgery
정회인 ( Jung Hoi-In ) - Yonsei University Department of Preventive Dentistry and Public Oral Health
최선규 ( Choi Sun-Kyu ) - Korea University college of Medicine Department of Biostatistics
Abstract
Background: Dental studies of precocious puberty have focused on examination of jaw and dentition growth. The aim of the study was to analyze the relationship between precocious puberty and maxillary dental developmental abnormalities (DDAs).
Methods: This retrospective study was conducted on the Korean patients in whom dental panoramic and hand-wrist radiographs had been taken before they were 15?years of age. The maxillary DDAs were assessed as mesiodens, congenital missing teeth, peg-shape lateral incisors, or impacted teeth. The chronological ages of the control group members were within the normal range of the hand-wrist bone age. Others with a peak luteinizing hormone of ≥ 5 and < 5?IU/L were allocated to central precocious puberty (CPP) and peripheral precocious puberty (PPP), respectively.
Results: Of the enrolled 270 patients, 195, 52, and 23 were allocated to the control, CPP, and PPP groups, respectively. The maxillary DDAs were significantly more prevalent in the CPP group than in the other groups. Among those with maxillary DDA, the mesiodens predominated. Age- and sex-adjusted multivariate analysis revealed maxillary DDA (odds ratio, 3.36; 95% CI, 1.60-7.05) and especially mesiodens (odds ratio, 5.52; CI, 2.29-13.28) to be significantly associated with CPP.
Conclusions: Maxillary DDAs were significantly more prevalent in the CPP group than in the PPP or control groups. Among the many types of maxillary DDAs, mesiodens was significantly associated with CPP and may be considered a predictor of the development of CPP.
키워드
Dental developmental abnormality; Gonadotropin-releasing hormone; Mesiodens; Precocious puberty; Supernumerary tooth
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