Association between periodontal bacteria and degenerative aortic stenosis: a pilot study
Kataoka Akihisa, Katagiri Sayaka, Kawashima Hideyuki, Nagura Fukuko, Nara Yugo, Hioki Hirofumi, Nakashima Makoto, Sasaki Naoki, Hatasa Masahiro, Maekawa Shogo,
소속 상세정보
( Kataoka Akihisa ) - Teikyo University Department of Medicine
( Katagiri Sayaka ) - Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Department of Periodontology
( Kawashima Hideyuki ) - Teikyo University Department of Medicine
( Nagura Fukuko ) - Teikyo University Department of Medicine
( Nara Yugo ) - Teikyo University Department of Medicine
( Hioki Hirofumi ) - Teikyo University Department of Medicine
( Nakashima Makoto ) - Teikyo University Department of Medicine
( Sasaki Naoki ) - Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Department of Periodontology
( Hatasa Masahiro ) - Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Department of Periodontology
( Maekawa Shogo ) - Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Department of Periodontology
Abstract
Purpose: Although several reports have described the relationship between periodontal disease and cardiovascular disease, information about the association between periodontal disease and the progression of degenerative aortic stenosis (AS) is lacking. Therefore, we performed a retrospective, single-center, pilot study to provide insight into this potential association.
Methods: Data from 45 consecutive patients (19 men; median age, 83 years) with mild or moderate degenerative aortic stenosis were analyzed for a mean observation period of 3.3±1.9 years. The total amount of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis and titers of serum immunoglobulin G (IgG) against periodontal bacteria and high-sensitivity C-reactive protein (hs-CRP) were evaluated. Aortic valve area (AVA), maximal velocity (Vmax), mean pressure gradient (mean PG), and the Doppler velocity index (DVI) were evaluated. The change in each parameter per year ([ParameterLATEST?ParameterBASELINE]/Follow-up Years) was calculated from the retrospective follow-up echocardiographic data (baseline vs. the most recently collected data [latest]).
Results: No correlation was found between the concentration of periodontopathic bacteria in the saliva and AS status/progression. The anti-P. gingivalis antibody titer in the serum showed a significant positive correlation with AVA and DVI. Additionally, there was a negative correlation between the anti-P. gingivalis IgG antibody titer and mean PG. The hs-CRP concentration showed positive correlations with Vmax and mean PG. Meanwhile, a negative correlation was observed between the anti-P. gingivalis IgG antibody titer and ΔAVA/year and Δmean PG/year. The hs-CRP concentration showed positive correlations with Vmax and mean PG, and it was significantly higher in patients with rapid aortic stenosis progression (ΔAVA/year
Conclusions: Our results suggest that periodontopathic bacteria such as A. actinomycetemcomitans and P. gingivalis are not directly related to the status/progression of degenerative AS. However, inflammation and a lower immune response may be associated with disease progression.
키워드
Aortic valve stenosis; C-reactive protein; Periodontal diseases; Porphyromonas gingivalis
원문 및 링크아웃 정보
등재저널 정보